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Intrathecal IL-6 is increased in PPMS. IL-6 levels in CSF of HCs vs. RRMS and PPMS measured with <t>Ella</t> ® . (A) IL-6 levels were significantly higher in PPMS vs. HCs ( p = 0.0428). Statistical significance was determined using the Mann-Whitney test. * p < 0.5. (B) Receiver operating characteristic (ROC) analysis demonstrated the capacity of IL-6 levels to distinguish between RRMS and PPMS with an area under the curve (AUC) of 0.7060, and statistical significance ( p = 0.0139)
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Intrathecal IL-6 is increased in PPMS. IL-6 levels in CSF of HCs vs. RRMS and PPMS measured with <t>Ella</t> ® . (A) IL-6 levels were significantly higher in PPMS vs. HCs ( p = 0.0428). Statistical significance was determined using the Mann-Whitney test. * p < 0.5. (B) Receiver operating characteristic (ROC) analysis demonstrated the capacity of IL-6 levels to distinguish between RRMS and PPMS with an area under the curve (AUC) of 0.7060, and statistical significance ( p = 0.0139)
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Intrathecal IL-6 is increased in PPMS. IL-6 levels in CSF of HCs vs. RRMS and PPMS measured with Ella ® . (A) IL-6 levels were significantly higher in PPMS vs. HCs ( p = 0.0428). Statistical significance was determined using the Mann-Whitney test. * p < 0.5. (B) Receiver operating characteristic (ROC) analysis demonstrated the capacity of IL-6 levels to distinguish between RRMS and PPMS with an area under the curve (AUC) of 0.7060, and statistical significance ( p = 0.0139)

Journal: BMC Neurology

Article Title: Intrathecal interleukin-6 levels are associated with progressive disease and clinical severity in multiple sclerosis

doi: 10.1186/s12883-025-04145-0

Figure Lengend Snippet: Intrathecal IL-6 is increased in PPMS. IL-6 levels in CSF of HCs vs. RRMS and PPMS measured with Ella ® . (A) IL-6 levels were significantly higher in PPMS vs. HCs ( p = 0.0428). Statistical significance was determined using the Mann-Whitney test. * p < 0.5. (B) Receiver operating characteristic (ROC) analysis demonstrated the capacity of IL-6 levels to distinguish between RRMS and PPMS with an area under the curve (AUC) of 0.7060, and statistical significance ( p = 0.0139)

Article Snippet: IL-6 was further quantified using Simple Plex Human NfL Cartridge with an Ella ® automated immunoassay system (Catalog # SPCKB-PS-003028, Protein Simple, San Jose, CA, USA, Table ).

Techniques: MANN-WHITNEY