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A <t>Peripheral</t> cytokine concentrations at baseline and 24 h after CEACAM5 x CD3 TCB administration in patients with low baseline soluble CEA (sCEA) ( n = 9), showing significant induction of IFNγ, TNFα, soluble IL-2 receptor (IL2SR), IL-10, IL-6 and IL-8. B Peripheral cytokine induction at 24 h stratified by baseline tumor immune phenotype ( n = 11), demonstrating significantly greater responses in immune-inflamed and excluded tumors compared with desert tumors for TNFa, IL-2 receptor and IL-6. Peripheral cytokines quantified using the ProteinSimple <t>Ella</t> platform. Concentrations are shown on log2-scaled y-axis.
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A <t>Peripheral</t> cytokine concentrations at baseline and 24 h after CEACAM5 x CD3 TCB administration in patients with low baseline soluble CEA (sCEA) ( n = 9), showing significant induction of IFNγ, TNFα, soluble IL-2 receptor (IL2SR), IL-10, IL-6 and IL-8. B Peripheral cytokine induction at 24 h stratified by baseline tumor immune phenotype ( n = 11), demonstrating significantly greater responses in immune-inflamed and excluded tumors compared with desert tumors for TNFa, IL-2 receptor and IL-6. Peripheral cytokines quantified using the ProteinSimple <t>Ella</t> platform. Concentrations are shown on log2-scaled y-axis.
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A Peripheral cytokine concentrations at baseline and 24 h after CEACAM5 x CD3 TCB administration in patients with low baseline soluble CEA (sCEA) ( n = 9), showing significant induction of IFNγ, TNFα, soluble IL-2 receptor (IL2SR), IL-10, IL-6 and IL-8. B Peripheral cytokine induction at 24 h stratified by baseline tumor immune phenotype ( n = 11), demonstrating significantly greater responses in immune-inflamed and excluded tumors compared with desert tumors for TNFa, IL-2 receptor and IL-6. Peripheral cytokines quantified using the ProteinSimple Ella platform. Concentrations are shown on log2-scaled y-axis.

Journal: NPJ Precision Oncology

Article Title: Early functional reactivity to a CEACAM5 x CD3 T cell bispecific antibody in solid tumors associates with baseline immune contexture rather than target antigen density alone

doi: 10.1038/s41698-026-01643-3

Figure Lengend Snippet: A Peripheral cytokine concentrations at baseline and 24 h after CEACAM5 x CD3 TCB administration in patients with low baseline soluble CEA (sCEA) ( n = 9), showing significant induction of IFNγ, TNFα, soluble IL-2 receptor (IL2SR), IL-10, IL-6 and IL-8. B Peripheral cytokine induction at 24 h stratified by baseline tumor immune phenotype ( n = 11), demonstrating significantly greater responses in immune-inflamed and excluded tumors compared with desert tumors for TNFa, IL-2 receptor and IL-6. Peripheral cytokines quantified using the ProteinSimple Ella platform. Concentrations are shown on log2-scaled y-axis.

Article Snippet: Peripheral cytokines quantified using the ProteinSimple Ella platform.

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